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(2020) found that histamine could induce microglial activation and the production of the pro-inflammatory cytokines TNF-α and IL-1β that was partially negated with H 1 and H 4 receptor antagonists and stimulated with H 1 and H 4 receptor agonists
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Specifically, downregulation of the neuronal lactate transporter MCT2 or the astroglial lactate transporter MCT4 in the rat barrel cortex abolished the lactate rise in response to sensory stimulation
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