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Another proposed mechanism for platinum drug resistance is the formation of adducts between the platinum drug and the cysteinyl-glycine product of γGT

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This limiting current is proportional to the concentration of the electroactive species (Ox in this case) as expressed by the following equation: where i is the measured current in amperes, n equals the number of electrons in the electrochemical reaction (reduction in this case), F is Faraday’s constant (96,487 coulombs/mol), A is the electrochemical surface area of the working electrode (in cm 2 ) (assuming a planar electrode geometry), D is the diffusion coefficient (in cm 2 /sec) of the electroactive species (Ox in this case), is the diffusion layer thickness (in cm), and C is the concentration of the analyte species in mol/cm 3

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