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doi: 10.3389/fimmu.2024.1352946 124 MaoP.WangZ.YuanC.LiuK.GuoL.DongJ.et al
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Previous RCTs in critical care/population settings and methodological issues In 2014, the VITDAL study showed no benefit of vitamin D supplementation on the primary endpoint in 480 mixed critically ill patients with vitamin D deficiency (defined as 25OHD 1,000 patients), the VIOLET study (35), showed no benefit of vitamin D in a less severely ill patient group (patients “with risk for ARDS” were included outside of the ICU, i.e., in the theater, the ward, or the emergency room)
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