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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Arvin P, Ghafouri S, Bavarsad K, Hajipour S, Khoshnam SE, Sarkaki A, and Farbood Y

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Moreover, a clinical trial demonstrated that treatment with 20 mg/kg/day sapropterin dihydrochloride significantly improved social awareness, mannerisms, hyperactivity, and inappropriate speech, compared to a placebo in ASD affected individuals [60]