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doi: 10.1182/blood-2018-07-818211
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Cibinetide (ARA-290): A More Preventative, Balanced Anti-Inflammatory Approach In contrast, cibinetide (ARA-290), when given systemically (typically via subcutaneous injection), circulates and reduces inflammation more directly through selective activation of the innate repair receptor (IRR) — a heterocomplex (EPOR/β-common receptor or CD131) that is upregulated primarily on cells in response to tissue injury, hypoxia, metabolic stress, or inflammation
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