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But under oxidative stress conditions induced by reactive species, toxins or ARE inducers, the association between Nrf2 and Keap1 is disrupted and Nrf2 translocates to the nucleus of the cell, where it binds to small Maf proteins that increase the transcription of genes driven by ARE [67]
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Although the role of amylin in obesity has been modestly researched in animal models, more studies are needed to clarify its role in human diseases [24]
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