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Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo
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These differences manifest in sex‐biased neurodegeneration pathologies—post‐menopausal females show 2‐fold higher Alzheimer's incidence (linked to estrogen loss and APOE4‐tau interactions), whereas males have 1.5‐fold greater Parkinson's risk (associated with iron accumulation in substantia nigra) [156]
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