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It is important to note that apoptosis occurs mainly through activation of a mitochondrial intrinsic pathway, which depends on caspase 9 and apoptotic protease activating factor 1 (Apaf1) or via an extrinsic pathway mediated by the Fas ligand and tumor necrosis factor receptor (TNFR) and by activation of caspase 8
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Based on clinical trials like Lee et al
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