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In other embodiments, ultrasonic devices, flow through homogenizers or supercritical CO2 devices are used to prepare nanoparticles

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Notably, the glutathione cycle has also been shown capable of compensating for reductions in glia-derived glutamine when the glutamine-glutamate shuttle is pharmacologically disrupted, suggesting it may serve as a secondary reservoir that sustains synaptic glutamate supply under conditions of metabolic stress [52]

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