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This is caused by an imbalance between factors that relax the endothelium, such as nitric oxide (NO), prostacyclin (PGI 2 ), and down regulation of endothelioum-dependent hyperpolarization (EDH) and factors that cause contraction such as thromboxane A 2 (TxA 2 ) and upregulation of endothelin-1 (ET-1)
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The whole collagen synthesis process begins in the nuclei of fibroblasts, where specific genes for pro-α1 and pro-α2 chains are transcribed into mRNA
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