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43 The main metabolic fuel of the red blood cell is plasma glucose, and its breakdown within the red blood cell provides 2 key compounds: adenosine triphosphate (ATP), required mainly for the operation of the cation pump, and nicotinamide adenine dinucleotide phosphate, reduced (NADPH), required mainly for keeping up the supply of reduced glutathione (GSH) essential for the detoxification of hydrogen peroxide (H 2 O 2 ) and of other reactive oxygen species (ROS)

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Localized to the plasma membrane, FSP1 utilizes NADPH as an electron donor to reduce CoQ10 to its antioxidant form, ubiquinol

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