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From the previous section, it follows that inherited disorders leading to dramatic elevations of homocysteine in the blood and urine derive from genetic defects in homocysteine transsulfuration or re-methylation, or in the transporters and enzymes involved in the delivery and metabolism of the key cofactors required for these metabolic pathways (specifically folate and vitamin B12)
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Fluorescence intensity was analyzed using ImageJ (v1.54 f) software (National Institutes of Health), with the regions of interest (ROIs) selected using the threshold function
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