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doi: 10.1016/j.foodchem.2012.02.101 91
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Key molecular drivers include elevated TGF-beta (driving fibroblast-to-myofibroblast differentiation and collagen overproduction), elevated inflammatory cytokines (IL-1, IL-6, TNF-alpha), increased matrix metalloproteinase activity, and neovascularization with accompanying nerve ingrowth that contributes to pain
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