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È stato identificato nel 1973 dal ricercatore Loren Pickart nel plasma umano, dove svolge un ruolo nella segnalazione della riparazione tissutale

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We have four laboratories working collaboratively on that same mission, to try to figure out how to restore vision either by the type of thing you’re doing where you’re restoring the cells that are already there, and enabling them to regrow their connection to the brain, or even in the idea of being able to put stem cells into the eye that could form new retinal ganglion cells, and again reconnect to the brain