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However, in two recent randomized clinical trials, Skinner et al (109) and Tsakiridis et al (110) reported poorer outcomes for patients with NSCLC treated with metformin in combination with radiotherapy, suggesting that the addition of metformin to radiotherapy did not improve OS in patients with NSCLC and increased toxicities, which contrasts the results of previous studies

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ROS scavenging and detoxification The antioxidant capacity of GSH derives from its thiol group, which confers potent reducing activity toward ROS, including superoxide anions and H 2 O 2 88