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6.8.1 Wnt/β-catenin signaling In the case of Wnt/β-catenin signaling (the canonical pathway), when the ligands (such as Wnt1, Wnt2, Wnt3, Wnt8a, and Wnt10b) bind to the Frizzled (FZD) receptors and LRP5/6 co-receptors, signaling is activated, leading to the recruitment of axis inhibition protein (AXIN1/2) and Dishevelled (DVL), which can inhibit the β-catenin destruction complex (consisting of AXIN, GSK3β, CK1, and APC) (233)

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