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The ethacrynic acid (a strong diuretic drug) is conjugated to 2-amino-2-deoxy-D-glucose to reduce diuretic effects but maintaining the inhibitory capacity against GSTP1-1, the ethacrynic acid derivatives are molecules with promising anti-proliferative activities against cancer cells [110]

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The rationale is physiological: elevated blood glucose and circulating somatostatin blunt GH release, and a nutrient load — especially fat — can attenuate the GH pulse a secretagogue is trying to amplify

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