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However, growing evidence has revealed several limitations associated with probiotic use, including reduced viability, instability during processing and storage, interindividual variability in colonization, and potential safety concerns in vulnerable populations, prompting the search for alternative microbiome-derived strategies 3,4

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It is clear that the QVD-OPH caspase inhibitor only slightly reduced the amount of apoptotic or dead cells and did not change the ratio of apoptotic to dead cells (around 47.7% of cells instead of 55.9%) in As 2 O 3 -treated cells, whereas it efficiently abrogated cell death in the NaAsO 2 -treated cells (Fig 1E and 1F), suggesting that the As 2 O 3 induced cell death follows a caspase-independent mechanism