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Because of its more ubiquitous expression than GSNO reductase and carbonyl reductase, several investigators have hypothesized that the Trx system is the primary regulator of the S-nitroso proteome in most tissues, a concept supported by evidence that nearly all small (23–30 kDa) S-nitrosated proteins in HepG2 cells are targets for denitrosation by the thioredoxin system [89]